The Top 5 Leaky Gut Supplements Of 2025
Updated 04/02/2025Here’s what you need to know when searching for a supplement to combat leaky gut.
If you’ve ever experienced digestive issues, food sensitivity, intense sugar and junk food cravings, fluctuating weight, brain fog, fatigue, headaches, skin rashes, or persistent UTIs, then you may be surprised to learn that all these symptoms have one thing in common — leaky gut syndrome.
Leaky gut syndrome is a condition where your intestinal lining is worn down, making it easier for harmful toxins to breakthrough into your bloodstream and wreak havoc on your health.
You see, in addition to breaking down food, your digestive tract is integral in protecting your body from toxins and other harmful substances. That’s because the walls of your digestive tracts act like barriers, controlling what enters your bloodstream that’s later transported to your organs.
Tight junctions, which are the small gaps in the intestinal wall, allow water and other nutrients to pass through. These tight junctions also block the passage of harmful substances.
So when your gut wall’s lining is worn down by things like too much sugar, yeast overgrowth, alcohol, stress, or even NSAIDs such as ibuprofen, this can cause the tight junctions in the intestinal wall to loosen up, allowing the bad stuff to leak through.
This can lead to a host of problems, ranging from digestive issues, increase in junk food cravings, fluctuating weight, yeast infections, fatigue, mood swings, and headaches.
The Gut Immune System Connection
Our immune system is a complex collaboration between our organs. This process involves cells and antibodies working together to fight off invading germs that can cause us harm.
However, 70% of our immune system comes from our gut. That's why its crucial to maintain our gut health, and a quality leaky gut supplement can help fortify our system against foreign pathogens.
How To Find A Supplement To Combat Leaky Gut Syndrome
Considering how far-reaching the impact of leaky gut can have on your overall health and well-being, it’s no wonder supplements that promise to prevent it and strengthen your digestive tract are more popular than ever.
Unfortunately, not all of these supplements are actually effective at addressing leaky gut and improving your health. In fact, many brands will cut corners, filling their supplements with harmful additives and using ineffective ingredients or weak dosages.
That’s why Consumer Survey created this guide to help you better understand what to look for in a great leaky gut supplement that will deliver noticeable results. We’ve also researched 74 leaky gut supplements to uncover the good, the bad, and the downright ugly.
How A Quality Leaky Gut Supplement Improve Your Health?
But before we dive into how to find the right leaky gut supplement, it’s important to understand how a top-notch leaky gut supplement can help improve your overall health.
Over time, a good leaky gut supplement that’s been formulated with the right ingredients can:
Improve Digestion
Help Rebuild Gut Lining
Help Improve Mood
Increase Energy Levels
Help Balance Blood Sugar Levels
Improve Nutritional Absorption
But to get these amazing health benefits, it’s important that you find a leaky gut supplement with the following ingredients:
Top Leaky Gut-Busting Ingredients To Look For:
L-Glutamine
This unique amino acid has been shown to strengthen the intestinal wall and regulate tight junctions. Since this is such a vital ingredient to healing leaky gut, look for at least 1,500 mg of l-glutamine per serving.
Licorice Root
This powerhouse ingredient is able to help control helicobacter pylori, a detrimental bacteria that can enter your body through your digestive tract, causing ulcers and inflammation. That’s why we highly recommend looking for a clinically studied version of this ingredient, such as Gutgard, at 150mg per dosage.
Acacia Fibergum
Acacia fibergum comes from the sap of the Acacia tree, which is a small, shrub-like plant native to Africa. Packed with tons of soluble fiber, acacia fibergum gets broken down into beneficial short-chain fatty acids, which have a healing effect on your intestinal wall lining.
Prebiotics
When it comes to getting leaky gut under control, prebiotics are essential. Prebiotics act like fuel for the good bacteria in your gut and super-charge them to get to work repairing and balancing your microbiome — fast. And one of the most powerful prebiotics on the market is human milk oligosaccharide, also known as HMO. Due to some amazing medical advances, only one lab was able to synthesize this ingredient and harness it’s extraordinary prebiotic powers. So look for a supplement that lists HMO CARE4U as an ingredient to really jump start your journey to healing leaky gut.
BEWARE: Magnesium Stearate & Titanium Dioxide
These cheap fillers are used to help bind ingredients together and lubricate the supplement so it doesn’t gum up when it is run through the manufacturing machines. Magnesium stearate adds no nutritional value and can become toxic to your system. While titanium dioxide can compromise the health of your immune system. Low-quality leaky gut supplements typically include these fillers.
Your Definitive Leaky Gut Supplement Checklist
Ingredients aren’t the only important thing to watch out for. Here’s what else you need to pay attention to before buying a leaky gut supplement.
Money-back Guarantee
Look for a company that feels so confident in their product that they're willing to offer at least a 90-day 100% money-back guarantee. This shows that the company has invested the time and resources to create a product that can deliver results.
Clinically Studied Ingredients
It's the golden rule . Look for clinically studied ingredients that have been proven to deliver results. Though many leaky gut supplements contain licorice root and prebiotics, not all have been clinically tested and proven to achieve effective results.
Clinically Recommended Dosages
Some brands will use quality ingredients, but skimp out on dosages in order to save money. So even if you’re getting the right ingredients, if they’re not in their recommended dosages, you won’t experience the full benefits. We recommend looking for a supplement that lists at least 150 mg per serving of clinically studied version of licorice root, such as Gutgard, and at least 1,200 mg of l-glutamine.
Relying On Amazon Reviews
- Amazon is a fantastic marketplace and resource for many consumers, but sadly relying only on Amazon reviews can be tricky. That's because up to 60% of reviews on Amazon were paid for by shady third party companies. So when it comes to shopping on Amazon, just make sure to be extra vigilant and take it with a grain of salt.
The Results Are In...
After surveying over 8,000 user reviews and then carefully reviewing 74 products, only a select few passed our strict testing criteria listed above. Users reported enhanced health — from better digestion, increased energy, and sharper mental clarity, and more. Here are our top 3 picks for the best leaky gut supplements on the market today.
Top Picks are updated monthly based on testing and analyses:
Top Pick
Consumers Survey Recommended
- Formulated with quality, clinically studied ingredients
- Uses clinically recommended dosages
- Free from additives or fillers
- 90-day money-
back guarantee
#1: GutMD By 1MD Nutrition™
GutMD by 1MD Nutrition™ comes it at number 1 as the best leaky gut supplement on the market. This robust formula features potent clinically studied ingredients, a powerful dosage of l-glutamine, vegan capsule composition, and no synthetic fillers or additives. Plus, it’s the only product on the market today that contains HMO, one of the most powerful prebiotics available.
This was also the only product we could find that has been formulated by a top doctor.
Additionally, 1MD Nutrition™ backed their product with a comprehensive, 90-day, risk-free, money-back guarantee. This was a huge advantage compared to the competition, along with total effectiveness projections that rivaled any other supplement we found.
All in all, 1MD Nutrition™ is our top pick.
Buy Now > >
Rating
Call Vital Nutrients:
888-328-9992
#2: GI Repair Powder By Vital Nutrients
GI Repair Powder by Vital Nutrients is a good value leaky gut supplement. Its formula is made with a good proprietary blends that includes l-glutamine, but fails to use the clinically studied version of any of the ingredients. In other words, it lacks the bioavailability to deliver results effectively or quickly.
Overall, customers were happy with their purchase. Although some were a bit bothered that it came as a powder, so they had to prepare a smoothie every day in order to consume it.
For all these reasons, GI Repair Powder by Vital Nutrients is number 2 on our list.
Buy now > >Rating
Call Liver Medic Toll Free:
800-387-2278
#3: Leaky Gut Repair By Liver Medic
Rounding off our list is Leaky Gut Repair by Liver Medic. This supplement uses some powerful ingredients, such as l-glutamine and licorice root, but once again doesn't use the clinically studied version or powerful dosages of these ingredients. It also lacks some key ingredients, such as prebiotics and acacia fibergum.
However, it was formulated without any harmful additives or fillers, which gives it a boost in our rankings.
Over all, it’s a decent leaky gut supplement, but there are better ones available on the market.
Buy Now > >
#4: Leaky Gut Defense
Our 4th winner is Leaky Gut Defense by Pure Terapro.
This product lacks in prebiotics, an essential ingredient for a leaky gut supplement. But on the flip side, it contains high dosages of l-glutamine which is known to be helpful in treating leaky gut.
Leaky Gut Defense offers a 30-day money back guarantee, but only if it hasn't been opened. Overall, many customers were satisfied with this supplement, hence why it earned a spot on our list.
Buy Now > >
#5: Gut Formula
Last on our top 5 is Gut Formula by Ancient Nutrition. It contains a couple important ingredients, like l-glutamine, licorice root, and prebiotics. However, it's uncertain how potent they really are.
Although some customers report satisfactory results, most reviews complain of inconsistencies in the formulation. For this reason, Gut Formula makes it on the bottom of our list.
P.S. While 1MD Nutrition™ has the best leaky gut health supplement we've found, we would still love to hear about any others you've tried. If you have had a great experience of your own, please send me an email to Beverly@ConsumersSurvey.org with the details.
Sincerely,
Beverly Gratson,
Senior Health Editor
What We Do
ConsumersSurvey uses a unique three-step approach to reviewing the most popular products in the online marketplace
1. Research First we conduct in-house research with a highly qualified editorial team comprised of individuals who specialize in various fields.
2. SurveyWe survey our readers who have tried the product over time in order to learn from their experiences.
3. OpinionWe monitor public opinion in the world’s most popular marketplaces, from Amazon and eBay, to Bizrate and Pricegrabber.
As a consumer herself, Beverly is extremely dedicated to gathering and collecting reports and information and always on the lookout for highly-rated supplements. She's especially passionate about educating consumers in making wise decisions when it comes to purchasing health products.